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1

Use of fluorescence-activated cell sorter to isolate mutant mammalian cells deficient in an internal protein, dihydrofolate reductase

Gail Urlaub, Joan McDowell, Lawrence A. Chasin

Journal:

Somatic Cell and Molecular Genetics

Year:

1985

Language:

english

File:

PDF, 429 KB

english, 1985

2

In vivo photoreaction of a chiral cobalt complex: DNA cleavage by Co(DIP)33+ in mammalian cells

Lowell B. Chapnick, Lawrence A. Chasin, Adrienne L. Raphael, Jacqueline K. Barton

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1988

Language:

english

File:

PDF, 755 KB

english, 1988

3

The effect of ploidy on chemical mutagenesis in cultured chinese hamster cells

Lawrence A. Chasin

Journal:

Journal of Cellular Physiology

Year:

1973

Language:

english

File:

PDF, 706 KB

english, 1973

4

Immortalization of normal liver functions in cell culture: Rat hepatocyte-hepatoma cell hybrids expressing ornithine carbamoyltransferase activity

Lawrence E. Widman, Jonathan J. Golden, Lawrence A. Chasin

Journal:

Journal of Cellular Physiology

Year:

1979

Language:

english

File:

PDF, 616 KB

english, 1979

5

Multihormonal induction of α2u-globulin in an established rat hepatoma cell line

Lawrence E. Widman, Lawrence A. Chasin

Journal:

Journal of Cellular Physiology

Year:

1982

Language:

english

File:

PDF, 1.46 MB

english, 1982

6

Rat serum albumin synthesis in variant rat hepatoma cells

Joyce Wolf, Jonathan J. Golden, Lawrence A. Chasin

Journal:

Journal of Cellular Physiology

Year:

1983

Language:

english

File:

PDF, 1.11 MB

english, 1983

7

Splicing by cell type

Arias, Mauricio A, Ke, Shengdong, Chasin, Lawrence A

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 535 KB

english, 2010

8

Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate reductase promoter

Noé, Véronique, Alemany, Cristina, Chasin, Lawrence A, Ciudad, Carlos J

Journal:

Year:

1998

Language:

english

File:

PDF, 480 KB

english, 1998

9

Cointegration of DNA Molecules Introduced into Mammalian Cells by Electroporation

Chao Chen, Lawrence A. Chasin

Journal:

Somatic Cell and Molecular Genetics

Year:

1998

Language:

english

File:

PDF, 2.29 MB

english, 1998

10

Mapping and characterization of mutations induced by benzo[a]pyrene diol epoxide at dihydrofolate reductase locus in CHO cells

Adelaide M. Carothers, Gail Urlaub, Dezider Grunberger, Lawrence A. Chasin

Journal:

Somatic Cell and Molecular Genetics

Year:

1988

Language:

english

File:

PDF, 1.68 MB

english, 1988

11

Polyadenylation of Chinese hamster dihydrofolate reductase genomic genes and minigenes after gene transfer

Lee Venolia, Gail Urlaub, Lawrence A. Chasin

Journal:

Somatic Cell and Molecular Genetics

Year:

1987

Language:

english

File:

PDF, 1.40 MB

english, 1987

12

Mutants of Chinese hamster ovary cells with altered glucose-6-phosphate dehydrogenase activity

Maurice J. Rosenstraus, Lawrence A. Chasin

Journal:

Somatic Cell and Molecular Genetics

Year:

1977

Language:

english

File:

PDF, 726 KB

english, 1977

13

Transformation of the gene for hypoxanthine phosphoribosyltransferase

Lloyd H. Graf, Gail Urlaub, Lawrence A. Chasin

Journal:

Somatic Cell and Molecular Genetics

Year:

1979

Language:

english

File:

PDF, 923 KB

english, 1979

14

Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions

Gail Urlaub, Pamela J. Mitchell, Emmanuel Kas, Lawrence A. Chasin, Vicky L. Funanage, T. Timothy Myoda, Joyce Hamlin

Journal:

Somatic Cell and Molecular Genetics

Year:

1986

Language:

english

File:

PDF, 1.46 MB

english, 1986

15

Gene amplification and vector engineering to achieve rapid and high-level therapeutic protein production using the Dhfr-based CHO cell selection system

Jonathan J. Cacciatore, Lawrence A. Chasin, Edward F. Leonard

Journal:

Biotechnology Advances

Year:

2010

Language:

english

File:

PDF, 395 KB

english, 2010

16

Cell-Growth Regulation of the Hamster Dihydrofolate Reductase Gene Promoter by Transcription Factor Sp1

Véronique Noé, Chao Chen, Cristina Alemany, Marta Nicolás, Isabel Caragol, Lawrence A. Chasin, Carlos J. Ciudad

Journal:

Year:

1997

Language:

english

File:

PDF, 1.02 MB

english, 1997

17

Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition

Yang Yu, Patricia A. Maroney, John A. Denker, Xiang H.-F. Zhang, Olexandr Dybkov, Reinhard Lührmann, Eckhard Jankowsky, Lawrence A. Chasin, Timothy W. Nilsen

Journal:

Year:

2008

Language:

english

File:

PDF, 1.46 MB

english, 2008

18

Computational searches for splicing signals

Xiang H.-F. Zhang, Christina S. Leslie, Lawrence A. Chasin

Journal:

Year:

2005

Language:

english

File:

PDF, 278 KB

english, 2005

19

DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells

Adelaide M. Carothers, Ronald W. Steigerwalt, Gail Urlaub, Lawrence A. Chasin, Dezider Grunberger

Journal:

Journal of Molecular Biology

Year:

1989

Language:

english

File:

PDF, 2.75 MB

english, 1989

20

The isolation of CHO cells with a site conferring a high and reproducible transgene amplification rate

Cacciatore, Jonathan J., Leonard, Edward F., Chasin, Lawrence A.

Journal:

Journal of Biotechnology

Year:

2013

Language:

english

File:

PDF, 692 KB

english, 2013

21

Intronic motif pairs cooperate across exons to promote pre-mRNA splicing

Shengdong Ke, Lawrence A Chasin

Journal:

Year:

2010

Language:

english

File:

PDF, 4.65 MB

english, 2010

22

Use of a selectable reporter for the isolation of mammalian regulatory genes

Morris, Arvia E., Jiang, Yajuan, McChesney, Ruth E., Jackson, Arthur E., Bancroft, Carter, Chasin, Lawrence A.

Journal:

Year:

1990

Language:

english

File:

PDF, 616 KB

english, 1990

23

Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells

Chasin, Lawrence A.

Journal:

Year:

1974

Language:

english

File:

PDF, 516 KB

english, 1974

24

REMEMBER THE AMŒBA

Chasin, Lawrence A.

Journal:

Year:

1962

Language:

english

File:

PDF, 165 KB

english, 1962

25

Anchorage of the Chinese hamster dihydrofolate reductase gene to the nuclear scaffold occurs in an intragenic region

Käs, Emmanuel, Chasin, Lawrence A.

Journal:

Journal of Molecular Biology

Year:

1987

Language:

english

File:

PDF, 8.29 MB

english, 1987

26

Efficient Cloning of Single-Copy Genes Using Specialized Cosmid Vectors: Isolation of Mutant Dihydrofolate Reductase Genes

Gail Urlaub, Adelaide M. Carothers and Lawrence A. Chasin

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.45 MB

english, 1985

27

Characterization of Mutations Induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the Dihydrofolate Reductase Gene of Cultured Hamster Cells

Adelaide M. Carothers, Gail Urlaub, Ronald W. Steigerwalt, Lawrence A. Chasin and Dezider Grunberger

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 1.16 MB

english, 1986

28

Genetics of Somatic Mammalian Cells, X. Complementation Analysis of Glycine-Requiring Mutants

Fa-Ten Kao, Lawrence Chasin and Theodore T. Puck

Journal:

Proceedings of the National Academy of Sciences

Year:

1969

Language:

english

File:

PDF, 328 KB

english, 1969

29

Reversion of a Chinese Hamster Cell Auxotrophic Mutant

Lawrence A. Chasin, Aileen Feldman, Marvin Konstam and Gail Urlaub

Journal:

Proceedings of the National Academy of Sciences

Year:

1974

Language:

english

File:

PDF, 827 KB

english, 1974

30

Isolation of Mammalian Cell Mutants Deficient in Glucose-6-phosphate Dehydrogenase Activity: Linkage to Hypoxanthine Phosphoribosyl Transferase

Maurice Rosenstraus and Lawrence A. Chasin

Journal:

Proceedings of the National Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 1.27 MB

english, 1975

31

Amplified Dihydrofolate Reductase Genes are Localized to a Homogeneously Staining Region of a Single Chromosome in a Methotrexate-Resistant Chinese Hamster Ovary Cell Line

Jack H. Nunberg, Randal J. Kaufman, Robert T. Schimke, Gail Urlaub and Lawrence A. Chasin

Journal:

Proceedings of the National Academy of Sciences

Year:

1978

Language:

english

File:

PDF, 1.33 MB

english, 1978

32

DNA-Mediated Transfer of the Adenine Phosphoribosyltransferase Locus into Mammalian Cells

Michael Wigler, Angel Pellicer, Saul Silverstein, Richard Axel, Gail Urlaub and Lawrence Chasin

Journal:

Proceedings of the National Academy of Sciences

Year:

1979

Language:

english

File:

PDF, 933 KB

english, 1979

33

[Part 2: Biological Sciences] || Isolation of Chinese Hamster Cell Mutants Deficient in Dihydrofolate Reductase Activity

Gail Urlaub and Lawrence A. Chasin

Journal:

Proceedings of the National Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 997 KB

english, 1980

34

Chemistry of Ethylenimines. X. Reactions with Phosphorus Nitrilochloride Trimer

Kobayashi, Yoshiro, Chasin, Lawrence A., Clapp, Leallyn B.

Journal:

Inorganic Chemistry

Year:

1963

Language:

english

File:

PDF, 384 KB

english, 1963

35

Introduction of Purified Genes Into Mammalian Cell

Kucherlapati, Raju, Skoultchi, I., Chasin, Lawrence

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Year:

1984

Language:

english

File:

PDF, 2.47 MB

english, 1984

36

An alternatively spliced Pit-1 isoform altered in its ability to trans-activate

Morris, Arvia E., Kloss, Brian, McChesney, Ruth E., Bancroft, Carter, Chasin, Lawrence A.

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 2.23 MB

english, 1992

37

Quantitative evaluation of all hexamers as exonic splicing elements

Ke, Shengdong, Shang, Shulian, Kalachikov, Sergey M., Morozova, Irina, Yu, Lin, Russo, James J., Ju, Jingyue, Chasin, Lawrence A.

Journal:

Genome Research

Year:

2011

Language:

english

File:

PDF, 1.50 MB

english, 2011

38

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells

Carothers, Adelaide M., Urlaub, Gail, Ellis, Nathan, Chasin, Lawrence A.

Journal:

Nucleic Acids Research

Year:

1983

Language:

english

File:

PDF, 3.63 MB

english, 1983

39

CRISPR-Cas targeted plasmid integration into mammalian cells via non-homologous end joining

Bachu, Ravichandra, Bergareche, Iñigo, Chasin, Lawrence A.

Journal:

Biotechnology and Bioengineering

Year:

2015

Language:

english

File:

PDF, 709 KB

english, 2015

40

A mutational hot spot induced by N -hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells

Carothers, Adelaide M., Urlaub, Gail, Mucha, Jitka, Yuan, Wei, Chasin, Lawrence A., Grunberger, Dezider

Journal:

Year:

1993

Language:

english

File:

PDF, 461 KB

english, 1993

41

The rat albumin gene promoter is appropriately regulated in transient but not in stable transfections

Berland, Robert, Chasin, Lawrence A.

Journal:

Nucleic Acids Research

Year:

1988

Language:

english

File:

PDF, 2.92 MB

english, 1988

42

Context-dependent splicing regulation

Ke, Shengdong, Chasin, Lawrence A.

Journal:

Year:

2011

Language:

english

File:

PDF, 493 KB

english, 2011

43

Non-linkage of Induced Mutations in Chinese Hamster Cells

CHASIN, LAWRENCE A.

Journal:

Nature New Biology

Year:

1972

File:

PDF, 362 KB

1972

44

Correction of point mutations at the endogenous locus of the dihydrofolate reductase gene using repair-PolyPurine Reverse Hoogsteen hairpins in mammalian cells

Solé, Anna, Ciudad, Carlos J., Chasin, Lawrence A., Noé, Véronique

Journal:

Biochemical Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

45

Splicing Mutations in the CHO DHFR Gene Preferentially Induced by (±)-3α, 4β-dihydroxy-1α, 2α-epoxy-1,2,3,4- Tetrahydrobenzo [k c ] Phenanthrene

Adelaide M. Carothers, Gail Urlaub, Jitka Mucha, Ronald G. Harvey, Lawrence A. Chasin and Dezider Grunberger

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 829 KB

english, 1990

46

[Methods in Enzymology] Volume 151 || [34] Repetitive cloning of mutant genes using locus-specific sticky ends

Chasin, Lawrence A

Year:

1987

Language:

english

File:

PDF, 1.78 MB

english, 1987

47

Saturation mutagenesis reveals manifold determinants of exon definition

Ke, Shengdong, Anquetil, Vincent, Zamalloa, Jorge Rojas, Maity, Alisha, Yang, Anthony, Arias, Mauricio A., Kalachikov, Sergey, Russo, James J., Ju, Jingyue, Chasin, Lawrence A.

Journal:

Genome Research

Year:

2017

Language:

english

File:

PDF, 6.23 MB

english, 2017

48

A doubly auxotrophic CHOâK1 cell line for the production of recombinant monoclonal antibodies

Zhang, Qinghao, Jiang, Bo, Du, Zhimei, Chasin, Lawrence

Journal:

Biotechnology and Bioengineering

Year:

2020

File:

PDF, 855 KB

2020